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Ji-Wang Chern
Title：Professor Emeritus
Email：jwchern@ntu.edu.tw
NTU SCHOLAR
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Education:Ph.D in Medicinal Chemistry, University of Michigan,USA
Experience:Professor and Director, Medical Laboratories, National Defense Medical Center (1986-1996).
Chairman, School of Pharmacy (2000-2005).
Dean, Office of Research and Development, National Taiwan University (2006~ 2012).
Chairman, Center for innovative Therapeutics Discovery, NTU (2013~now).
Honor:Fellow, American Association for the Advancement of Science, 2001.
Research Areas:Design and developement of new drugs, Heterocyclic Chemistry, Pharmaceutical Chemistry
Lab Focus:This laboratory is focused on the new anticancer, antiviral, CNS and cardio- vascular drug discovery. The approaches are taken by either generating the hypothetic 3D structure through existing compounds through computer modeling program or directly using the X-Ray 3D structure of enzymatic protein, followed a virtually high through-put screening via docking through a variety of data bases to provide a new ead compound. Then the traditional approaches toward the lead optimization for new drug development are applied . On the basis of these approaches , current ongoing research projects include : design and synthesis of selective A1a-adrenoceptor and 5a-reductase inhibitor for the treatment of benign hypertrophy , design and synthesis of helicase inhibitors against hepatitis C, design and synthesis of adenosine A1 agonist for the treatment of arrhythmia,design and synthesis multi-drug resistance tumor reversing agents, and design and synthesis of tyrosine kinase inhibitors.