1. Lin, Ching; Hsu, Jui-Ling; Hsu, Yu-Tung; Fan, Kuo-Chen; Wu, Sian-Siou Lin, Miao-Hsia; Guh, Jih-Hwa; Yu, Chao-Wu* (2025). Design and Synthesis of Novel HDAC6 inhibitor Dimer as HDAC6 Degrader for Cancer Treatment by Palladium Catalysed Dimerisation. Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, https://doi.org/10.1080/14756366.2025.2468355

2. Lin, Ching; Chiang, Hsin-Yi; Chen, Grace Shiahuy; Chern, Ji-Wang; Yu, Chao-Wu *Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity. Bioorganic & Medicinal Chemistry Letters, 2025, https://doi.org/10.1016/j.bmcl.2025.130105

3. Kang-li Wang, Tsung-Yu Yeh, Pei-Chen Hsu, Tzu-Hsuan Wong, Jia-Rong Liu, Ji-Wang Chern, Miao-Hsia Lin, Chao-Wu Yu. Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39, 1, 2318645 (SCI)

4. Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Zi-Yuan Wei, Yi-Chin Chen, Yi-Chang Chiang, Jui-Ling Hsu, She-Hung Chan, Lih-Ching Hsu, Ji-Wang Chern, Chao-Wu Yu, Jih-Hwa Guh. A novel HDAC6 inhibitor interferes microtubule dynamics andspindle assembly checkpoint and sensitizes cisplatin‐inducedapoptosis in castration‐resistant prostate cancer.The Prostate.2024;e24678.doi:10.1002/pros.24678 (SCI)

5. Zhijian Pan, Min Shao, Chen Zhao, Xuanjun Yang, Haitao Li, Guozhen Cui, Xiaonan Liang, Chao-Wu Yu, Qingqing Ye, Cheng Gao, Lijun Di, Ji-Wang Chern, Hefeng Zhou, Simon Ming-Yuen Lee. J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice. European Journal of Pharmaceutical Sciences, 2024, Jan, doi.org/10.1016/j.ejps.2024.106696 (SCI)

6. Zhijian Pan, Chao-Wu Yu, Chen Zhao, Min Shao, Xuanjun Yang, Xiaonan Liang, Haitao Li, Yucong Lu, Qingqing Ye, Ji-Wang Chern, Jiahong Lu, Hefeng Zhou, Simon Ming-Yuen Lee. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome. Toxicology and Applied Pharmacology 2023, NOV, doi.org/10.1016/j.taap.2023.116745(SCI)

7. Wei-Chieh Yu, Tsung-Yu Yeh, Chih-Hung Ye, Patrick Chun Theng Chong, Yi-Hsun Ho, Dorothy Kazuno So, Kah Yi Yap, Guan-Ru Peng, Chi-Hsuan Shao, Ajit Dhananjay Jagtap,Ji-Wang Chern, Chen-Si Lin, Shau-Ping Lin, Shuei-Liong Lin, Shu-Han Yu,*, and Chao-Wu Yu*.Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry 2023, JUL, doi.org/10.1021/acs.jmedchem.3c00644 (cover story)(SCI)

8. Cheng Peng, Yu-Hsuan Li, Chao-Wu Yu, Ze-Hua Cheng, Jia-Rong Liu, Jui-Ling Hsu, Ling-Wei Hsin, Chen-Tsung Huang, Hsueh-Fen Juan, Ji-Wang Chern, Yi-Sheng Cheng* Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity 2021, MAY, 110, 104813 (SCI)

9. Jia-Rong Liu, Chao-Wu- Yu, Pei-Yun Hung, Ling-Wei Hsin, Ji-Wang Chern* High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma Biochemical Pharmacology 2019, MAY, 163, 458-471 (SCI)

10. Chao-Wu Yu, Pei-Yun Hung, Hui-Ting Yang, Yi-Hsun Ho, Hsing-Yi Lai, Yi-Sheng Cheng, and Ji-Wang Chern* Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small-Cell Lung Cancer. Journal of Medicinal Chemistry 2019, JAN, 62 (2), 857-874 (cover story) (SCI)

11. Yi-Hsun Ho, Kuang-Jui Wang, Pei-Yun Hung, Yi-Sheng Cheng, Jia-Rong Liu, Sheang-Tze Fung, Pi-Hui Liang, Ji-Wang Chern* and Chao-Wu Yu* A highly HDAC6-selective inhibitor acts as a fluorescent probe. Organic & Biomolecular Chemistry. 2018, NOV, 16, 7820-7832 (cover story) (SCI)

12. Chawalit Siriboon, Tzai-Shiuan Li, Chao-Wu Yu, Ji-Wang Chern, Jyh-Cherng Ju* Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigs PLoS ONE 2018, SEP, 13(9):e0204588 (SCI)

13. Pei-Teh Chang, Rahul Subhash Talekar, Fan-LuKung, Ting-Rong Chern, Chen-Wei Huang, Qing-qing Ye, Min-Yan Yang, Chao-Wu Yu, Shin-Yu Lai, Ravindra Ramesh Deore, Jung-Hsin Lin, Chien-Shu Chen, Grace Shiahuy Chen, Ji-WangChern* A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth Neuropharmacology 2015, MAY, 92, 146-157 (SCI)

14. Chao-Wu Yu, Pei-Teh Chang, Ling-Wei Hsin, and Ji-Wang Chern* Quinazolin-4-one Derivatives as Selective Histone Deacetylase‑6 Inhibitors for the Treatment of Alzheimer’s Disease Journal of Medicinal Chemistry, 2013, SEP, 56 (17), 6775–6791 (SCI)

15. Chao-Wu Yu, Grace S. Chen, Chen-Wei Huang, and Ji-Wang Chern. Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate Organic Letters, 2012, JUL, 14 (14), 3688–3691 (SCI)

16. Khanwelkar, R. R.; Chen, G. S.; Wang, H.-C.; Yu, C.-W.; Huang, C.-H.; Lee, O.; Chen, C.-H.; Hwang, C.-S.; Ko, C.-H.; Chou, N.-T.; Lin, M.-W.; Wang, L.-m.; Chen, Y.-C.; Hseu, T.-H.; Chang, C.-N.; Hsu, H.-C.; Lin, H.-C.; Shih, Y.-C.; Chou, S.-H.; Tseng, H.-W.; Liu, C.-P.; Tu, C.-M.; Hu, T.-L.; Tsai, Y.-J.; Chern, J.-W: Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors Bioorganic & Medicinal Chemistry 2010, 18 (13), 4674-4686 (SCI)

17. Patents

18. QUINAZOLINE DERIVATIVES USEFUL AS SELECTIVE HDAC6 INHIBITORS WO2021/252475 A1

19. HISTONEDEACETYLASES(HDACS) INHIBITORS US9,155,739B2

20. HISTONEDEACETYLASES(HDACS) INHIBITORS US9,387,209B2

21. HISTONEDEACETYLASES(HDACS) INHIBITORS WO2018/213364 A1

22. HISTONEDEACETYLASES(HDACS) INHIBITORS TWI481597B

23. HISTONEDEACETYLASES(HDACS) INHIBITORS EP2836484B1

24. HISTONEDEACETYLASES(HDACS) INHIBITORS JP6258918B2

25. HISTONEDEACETYLASES(HDACS) INHIBITORS IL235053A

26. HISTONEDEACETYLASES(HDACS) INHIBITORS CN104364237B

27. HISTONEDEACETYLASES(HDACS) INHIBITORS AU2013246278B2

28. HISTONEDEACETYLASES(HDACS) INHIBITORS US11535598B2

29. HISTONEDEACETYLASES(HDACS) INHIBITORS EP3624804B1

30. Quinazoline derivatives useful as selective hdac6 inhibitors US20230212129A1