1. Kang-li Wang, Tsung-Yu Yeh, Pei-Chen Hsu, Tzu-Hsuan Wong, Jia-Rong Liu, Ji-Wang Chern, Miao-Hsia Lin, Chao-Wu Yu. Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39, 1, 2318645 (SCI)

2. Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Zi-Yuan Wei, Yi-Chin Chen, Yi-Chang Chiang, Jui-Ling Hsu, She-Hung Chan, Lih-Ching Hsu, Ji-Wang Chern, Chao-Wu Yu, Jih-Hwa Guh. A novel HDAC6 inhibitor interferes microtubule dynamics andspindle assembly checkpoint and sensitizes cisplatin‐inducedapoptosis in castration‐resistant prostate cancer.The Prostate.2024;e24678.doi:10.1002/pros.24678 (SCI)

3. Zhijian Pan, Min Shao, Chen Zhao, Xuanjun Yang, Haitao Li, Guozhen Cui, Xiaonan Liang, Chao-Wu Yu, Qingqing Ye, Cheng Gao, Lijun Di, Ji-Wang Chern, Hefeng Zhou, Simon Ming-Yuen Lee. J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice. European Journal of Pharmaceutical Sciences, 2024, Jan, doi.org/10.1016/j.ejps.2024.106696 (SCI)

4. Zhijian Pan, Chao-Wu Yu, Chen Zhao, Min Shao, Xuanjun Yang, Xiaonan Liang, Haitao Li, Yucong Lu, Qingqing Ye, Ji-Wang Chern, Jiahong Lu, Hefeng Zhou, Simon Ming-Yuen Lee. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome. Toxicology and Applied Pharmacology 2023, NOV, doi.org/10.1016/j.taap.2023.116745(SCI)

5. Wei-Chieh Yu, Tsung-Yu Yeh, Chih-Hung Ye, Patrick Chun Theng Chong, Yi-Hsun Ho, Dorothy Kazuno So, Kah Yi Yap, Guan-Ru Peng, Chi-Hsuan Shao, Ajit Dhananjay Jagtap,Ji-Wang Chern, Chen-Si Lin, Shau-Ping Lin, Shuei-Liong Lin, Shu-Han Yu,*, and Chao-Wu Yu*.Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry 2023, JUL, doi.org/10.1021/acs.jmedchem.3c00644 (cover story)(SCI)

6. Cheng Peng, Yu-Hsuan Li, Chao-Wu Yu, Ze-Hua Cheng, Jia-Rong Liu, Jui-Ling Hsu, Ling-Wei Hsin, Chen-Tsung Huang, Hsueh-Fen Juan, Ji-Wang Chern, Yi-Sheng Cheng* Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity 2021, MAY, 110, 104813 (SCI)

7. Jia-Rong Liu, Chao-Wu- Yu, Pei-Yun Hung, Ling-Wei Hsin, Ji-Wang Chern* High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma Biochemical Pharmacology 2019, MAY, 163, 458-471 (SCI)

8. Chao-Wu Yu, Pei-Yun Hung, Hui-Ting Yang, Yi-Hsun Ho, Hsing-Yi Lai, Yi-Sheng Cheng, and Ji-Wang Chern* Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small-Cell Lung Cancer. Journal of Medicinal Chemistry 2019, JAN, 62 (2), 857-874 (cover story) (SCI)

9. Yi-Hsun Ho, Kuang-Jui Wang, Pei-Yun Hung, Yi-Sheng Cheng, Jia-Rong Liu, Sheang-Tze Fung, Pi-Hui Liang, Ji-Wang Chern* and Chao-Wu Yu* A highly HDAC6-selective inhibitor acts as a fluorescent probe. Organic & Biomolecular Chemistry. 2018, NOV, 16, 7820-7832 (cover story) (SCI)

10. Chawalit Siriboon, Tzai-Shiuan Li, Chao-Wu Yu, Ji-Wang Chern, Jyh-Cherng Ju* Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigs PLoS ONE 2018, SEP, 13(9):e0204588 (SCI)

11. Pei-Teh Chang, Rahul Subhash Talekar, Fan-LuKung, Ting-Rong Chern, Chen-Wei Huang, Qing-qing Ye, Min-Yan Yang, Chao-Wu Yu, Shin-Yu Lai, Ravindra Ramesh Deore, Jung-Hsin Lin, Chien-Shu Chen, Grace Shiahuy Chen, Ji-WangChern* A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth Neuropharmacology 2015, MAY, 92, 146-157 (SCI)

12. Chao-Wu Yu, Pei-Teh Chang, Ling-Wei Hsin, and Ji-Wang Chern* Quinazolin-4-one Derivatives as Selective Histone Deacetylase‑6 Inhibitors for the Treatment of Alzheimer’s Disease Journal of Medicinal Chemistry, 2013, SEP, 56 (17), 6775–6791 (SCI)

13. Chao-Wu Yu, Grace S. Chen, Chen-Wei Huang, and Ji-Wang Chern. Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate Organic Letters, 2012, JUL, 14 (14), 3688–3691 (SCI)

14. Khanwelkar, R. R.; Chen, G. S.; Wang, H.-C.; Yu, C.-W.; Huang, C.-H.; Lee, O.; Chen, C.-H.; Hwang, C.-S.; Ko, C.-H.; Chou, N.-T.; Lin, M.-W.; Wang, L.-m.; Chen, Y.-C.; Hseu, T.-H.; Chang, C.-N.; Hsu, H.-C.; Lin, H.-C.; Shih, Y.-C.; Chou, S.-H.; Tseng, H.-W.; Liu, C.-P.; Tu, C.-M.; Hu, T.-L.; Tsai, Y.-J.; Chern, J.-W: Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors Bioorganic & Medicinal Chemistry 2010, 18 (13), 4674-4686 (SCI)

15. Patents

16. QUINAZOLINE DERIVATIVES USEFUL AS SELECTIVE HDAC6 INHIBITORS WO2021/252475 A1

17. HISTONEDEACETYLASES(HDACS) INHIBITORS US9,155,739B2

18. HISTONEDEACETYLASES(HDACS) INHIBITORS US9,387,209B2

19. HISTONEDEACETYLASES(HDACS) INHIBITORS WO2018/213364 A1

20. HISTONEDEACETYLASES(HDACS) INHIBITORS TWI481597B

21. HISTONEDEACETYLASES(HDACS) INHIBITORS EP2836484B1

22. HISTONEDEACETYLASES(HDACS) INHIBITORS JP6258918B2

23. HISTONEDEACETYLASES(HDACS) INHIBITORS IL235053A

24. HISTONEDEACETYLASES(HDACS) INHIBITORS CN104364237B

25. HISTONEDEACETYLASES(HDACS) INHIBITORS AU2013246278B2